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Sarah R. Smith, Jeroen T. F. Gillard, Adam B. Kustka, John P. McCrow, Jonathan H. Badger, Hong Zheng, Chris L. Dupont, Toshihiro Obata, Alisdair R. Fernie, Andrew E. Allen
Transcriptional Orchestration of the Global Cellular Response of a Model Pennate Diatom to Diel Light Cycling under Iron Limitation
www.plosgenetics.org
www.plosgenetics.org
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4.4617 0 Td
(of)Tj
1.0148 0 Td
(genes)Tj
2.4435 0 Td
(involved)Tj
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(in)Tj
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(cell)Tj
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(and)Tj
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(ribosome)Tj
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(nitrogen)Tj
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(greatly)Tj
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(expand)Tj
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(the)Tj
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(of)Tj
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(sensitive)Tj
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(genes)Tj
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(involved)Tj
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(in)Tj
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(novel)Tj
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(Fe)Tj
1.1679 0 Td
(acquisition)Tj
4.6318 0 Td
(mechanisms)Tj
5.2043 0 Td
([)Tj
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(19)Tj
0 g
(],)Tj
2.075 0 Td
(and)Tj
-34.2536 -1.2983 Td
(identify)Tj
3.2938 0 Td
(specific)Tj
3.1918 0 Td
(transcription)Tj
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(factors)Tj
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(and)Tj
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(gene)Tj
2.0863 0 Td
(regulatory)Tj
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(utilized)Tj
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(by)Tj
1.1848 0 Td
(the)Tj
1.4684 0 Td
(model)Tj
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/F13 1 Tf
3.0727 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7(\r)-9()4()7()11(\r)-9()18()14()7()12()]TJ
/F9 1 Tf
5.006 0 Td
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1.0261 0 Td
(adapt)Tj
2.4321 0 Td
(to)Tj
1.0205 0 Td
(Fe-limitation.)Tj
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/F13 1 Tf
3.3846 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
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0.9978 0 Td
[()7(\r)-9()4()7()11(\r)-9()18()14()7()12()]TJ
/F9 1 Tf
5.0003 0 Td
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(not)Tj
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(ecologically)Tj
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(diatoms)Tj
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(because)Tj
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0.788 0 Td
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(a)Tj
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(low)Tj
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(susceptibility)Tj
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(highly)Tj
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(14)Tj
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(,)Tj
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(20)Tj
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(an)Tj
1.2019 0 Td
(in-depth)Tj
3.6794 0 Td
(view)Tj
2.0522 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(global)Tj
2.6248 0 Td
(cellular)Tj
3.1408 0 Td
(processes)Tj
3.9685 0 Td
(operating)Tj
4.0535 0 Td
(over)Tj
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(the)Tj
1.474 0 Td
(diel)Tj
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(cycle,)Tj
2.4151 0 Td
(leading)Tj
3.1351 0 Td
(to)Tj
1.0204 0 Td
(physiological)Tj
5.4482 0 Td
(acclimation)Tj
4.8869 0 Td
(to)Tj
1.0261 0 Td
(low)Tj
1.6554 0 Td
(Fe)Tj
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 431.3763 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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3.7984 0 Td
(and)Tj
1.989 0 Td
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/F0 1 Tf
-5.7874 -1.4976 Td
(Fe-limited)Tj
4.559 0 Td
(response)Tj
4.2804 0 Td
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/F0 1 Tf
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1.1575 0 Td
(tricornutum)Tj
ET
Q
q
1 j
1 J
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BT
/F9 1 Tf
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(cultures)Tj
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[()7(\r)-9()4()7()11(\r)-9()18()14()7()12()]TJ
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5.0003 0 Td
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2.126 0 Td
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2.7949 0 Td
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0.9524 0 Td
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(iron)Tj
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(\(Fe\))Tj
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(concentrations,)Tj
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(two)Tj
1.7064 0 Td
(of)Tj
1.0148 0 Td
(which)Tj
2.6532 0 Td
(were)Tj
2.1203 0 Td
(limiting)Tj
3.4016 0 Td
(at)Tj
0.9524 0 Td
(20)Tj
1.1679 0 Td
(pM)Tj
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(and)Tj
1.7291 0 Td
(40)Tj
1.1736 0 Td
(pM)Tj
1.627 0 Td
(Fe)Tj
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Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 401.3291 387.0425 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 405.9212 383.4141 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
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(\(low)Tj
1.9955 0 Td
(Fe\))Tj
1.5137 0 Td
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1.0375 0 Td
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(duplicate,)Tj
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(and)Tj
1.7292 0 Td
(non-)Tj
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0.9524 0 Td
(400)Tj
1.6498 0 Td
(pM)Tj
1.627 0 Td
(Fe)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 342.2551 374.0031 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 346.8472 370.3748 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(high)Tj
2.347 0 Td
(Fe\))Tj
1.5137 0 Td
(in)Tj
1.0375 0 Td
(biological)Tj
4.0875 0 Td
(triplicate)Tj
3.7701 0 Td
(over)Tj
1.9729 0 Td
(a)Tj
0.6519 0 Td
(12:12)Tj
2.3528 0 Td
(light:dark)Tj
-32.4167 -1.2982 Td
(cycle.)Tj
2.4151 0 Td
(Cultures)Tj
3.6396 0 Td
(were)Tj
2.1203 0 Td
(sampled)Tj
3.549 0 Td
(over)Tj
1.9786 0 Td
(a)Tj
0.6519 0 Td
(complete)Tj
3.8834 0 Td
(diel)Tj
1.6837 0 Td
(cycle,)Tj
2.4151 0 Td
(every)Tj
2.3471 0 Td
(4)Tj
0.6973 0 Td
(hr)Tj
1.1169 0 Td
(for)Tj
1.3889 0 Td
(28)Tj
1.1679 0 Td
(hr)Tj
1.1225 0 Td
(\(7)Tj
1.0375 0 Td
(time)Tj
2.0239 0 Td
(points\))Tj
-33.2387 -1.2983 Td
(resulting)Tj
3.7303 0 Td
(in)Tj
1.0319 0 Td
(a)Tj
0.6576 0 Td
(total)Tj
2.0012 0 Td
(of)Tj
1.0148 0 Td
(49)Tj
1.1736 0 Td
(time)Tj
2.0239 0 Td
(points)Tj
2.7212 0 Td
(sampled)Tj
3.5489 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
1.5137 0 Td
(Table)Tj
0 g
(\).)Tj
3.0047 0 Td
(Relative)Tj
3.3902 0 Td
(to)Tj
1.0261 0 Td
(high)Tj
2.007 0 Td
(Fe)Tj
1.1735 0 Td
(cultures,)Tj
3.6226 0 Td
(Fe)Tj
1.1736 0 Td
(limita-)Tj
-34.8148 -1.2982 Td
(tion)Tj
1.8425 0 Td
(reduced)Tj
3.4412 0 Td
(growth)Tj
3.0728 0 Td
(rates)Tj
2.1089 0 Td
(by)Tj
1.1849 0 Td
(25)Tj
1.1679 0 Td
(and)Tj
1.7291 0 Td
(28%)Tj
1.9331 0 Td
(at)Tj
0.9524 0 Td
(40)Tj
1.1679 0 Td
(pM)Tj
1.6328 0 Td
(Fe)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 411.8173 335.0551 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 416.4661 331.4267 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(20)Tj
1.1678 0 Td
(pM)Tj
1.6328 0 Td
(Fe)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 471.2881 335.0551 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 475.8803 331.4267 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(respectively)Tj
4.8812 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-35.2513 -1.3039 Td
(S1)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(S7)Tj
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2.6362 0 Td
(Figs\).)Tj
2.4094 0 Td
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1.2019 0 Td
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(conditions,)Tj
4.6998 0 Td
(cell)Tj
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(division)Tj
3.4185 0 Td
(peaked)Tj
3.0444 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.474 0 Td
(dark)Tj
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(phase)Tj
2.4831 0 Td
(\(26)Tj
2.0296 0 Td
(AM;)Tj
0.83 0.64 0.02 0 k
2.0239 0 Td
(Fig)Tj
1.4797 0 Td
(1A)Tj
0 g
(\).)Tj
-35.7502 -1.2982 Td
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4.3086 0 Td
(cell)Tj
1.559 0 Td
(division)Tj
3.4186 0 Td
(in)Tj
1.0375 0 Td
(phytoplankton)Tj
6.1228 0 Td
(is)Tj
0.8447 0 Td
(entrained)Tj
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(to)Tj
1.0262 0 Td
(light:dark)Tj
4.0762 0 Td
(cycles,)Tj
2.7778 0 Td
(however)Tj
3.6113 0 Td
(several)Tj
2.9367 0 Td
(dia-)Tj
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(tom)Tj
1.8425 0 Td
(species)Tj
2.999 0 Td
(including)Tj
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4.0422 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F13 1 Tf
0.9921 0 Td
[()7(\r)-9()4()7()11(\r)-9()18()14()7()12()]TJ
/F9 1 Tf
(,)Tj
5.227 0 Td
(have)Tj
2.0637 0 Td
(been)Tj
2.1203 0 Td
(difficult)Tj
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1.0261 0 Td
(synchronize)Tj
5.0625 0 Td
(based)Tj
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(on)Tj
1.2756 0 Td
(light:dark)Tj
-32.479 -1.3039 Td
(cycles)Tj
2.5511 0 Td
(alone)Tj
2.3811 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(36)Tj
0 g
(].)Tj
3.5433 0 Td
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2.5682 0 Td
(observations)Tj
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4.2576 0 Td
(with)Tj
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(small)Tj
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(degree)Tj
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3.0727 0 Td
(synchronization)Tj
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(observed)Tj
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(our)Tj
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(cultures)Tj
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(where)Tj
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(percentage)Tj
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1.0147 0 Td
(dividing)Tj
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(reached)Tj
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(c.)Tj
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(20%)Tj
1.9333 0 Td
(\()Tj
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(Fig)Tj
1.8198 0 Td
(1A)Tj
0 g
(\).)Tj
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1.1111 0 Td
(addition)Tj
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3.0728 0 Td
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(Fe)Tj
1.1679 0 Td
(availability)Tj
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(impacted)Tj
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Q
q
1 j
1 J
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7.4999 0 0 6.6659 476.5039 238.7338 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
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(v)Tj
ET
Q
q
1 j
1 J
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BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/F)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 488.4661 238.7338 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(m)Tj
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Q
q
1 j
1 J
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BT
/F9 1 Tf
1 TL
-0.004 Tc
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(,)Tj
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(\(the)Tj
1.8085 0 Td
(maximum)Tj
-31.7137 -1.2982 Td
(potential)Tj
3.7587 0 Td
(quantum)Tj
3.8835 0 Td
(efficiency)Tj
4.0251 0 Td
(of)Tj
1.0148 0 Td
(PSII\).)Tj
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(Average)Tj
3.4809 0 Td
(F)Tj
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Q
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1 J
0 w
7.4999 0 0 6.6659 391.9181 225.7511 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(v)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 395.3196 227.3952 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/F)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 403.8803 225.7511 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 412.2141 227.3952 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(of)Tj
/F13 1 Tf
1.0147 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
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0.9922 0 Td
[()7(\r)-9()4()7()11(\r)-9()18()14()7()12()]TJ
/F9 1 Tf
5.0059 0 Td
(grown)Tj
2.795 0 Td
(at)Tj
0.9524 0 Td
(400)Tj
1.6498 0 Td
(pM)Tj
1.627 0 Td
(Fe)Tj
ET
Q
q
1 j
1 J
0 w
6.9998 0 0 6.9998 562.1102 231.0236 cm
BT
/F14 1 Tf
1 TL
0 0 Td
(0)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 214.4125 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(was)Tj
1.6894 0 Td
(near)Tj
1.9899 0 Td
(the)Tj
1.4627 0 Td
(theoretical)Tj
4.4333 0 Td
(maximum)Tj
4.3653 0 Td
(\(F)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 348.0944 212.7118 cm
BT
/F9 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(v)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 351.496 214.4125 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
(/F)Tj
ET
Q
q
1 j
1 J
0 w
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